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Evaluation of Optimized Digital Fundus Reflex Photographs for Lens Opacities in the Age-Related Eye Disease Study 2: AREDS2 Report 7

Sep-13

Journal Article

Authors:

Domalpally, A.

Danis, R.P.

Chew, E.Y.

Clemons, T.E.

Reed, S.

SanGiovanni, J.P.

Group, T.AgeRelate

Secondary:
Invest Ophthalmol Vis Sci

Volume:
54

Pagination:
5989-5994

URL:
http://www.ncbi.nlm.nih.gov/pubmed/23887802

Keywords:
AREDS2; cataract; lens opacity

Abstract:
<p>{PURPOSE: We described the system for grading lens opacities using stereoscopic digital fundus reflex photographs in the Age-Related Eye Disease Study 2 (AREDS2) and compared reproducibility with the AREDS lens grading system, which used retroillumination film images. METHODS: Stereoscopic fundus reflex photographs were acquired in a standardized fashion at baseline and annually. Images were enhanced and evaluated in the red channel at a central reading center. Percentage involvement of cortical and posterior subcapsular (PSC) lens opacities within the central 5 mm diameter zone of a modified AREDS lens grid was estimated. Reproducibility was assessed for contemporaneous variability (ongoing, monthly regrade on 5% of submissions</p>

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