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MELD (The Model for End-Stage Liver Disease (MELD)) Score Is an Important Predictor of Pretransplantation Mortality in HIV-Infected Liver Transplant Candidates

Jan-10

Journal Article

Authors:

Subramanian, A.

Sulkowski, M.

Barin, B.

Stablein, D.

Curry, M.

Nissen, N.

Dove, L.

Roland, M.

Florman, S.

Blumberg, E.

Stosor, V.

Jayaweera, D.

Huprikar, S.

Fung, J.

Pruett, T.

Stock, P.

Ragni, M.

Secondary:
Gastroenterology

Volume:
138

Pagination:
159-164

URL:
http://www.ncbi.nlm.nih.gov/pubmed/19800334

Keywords:
Adult; Cohort Studies; Female; Hepatitis C; HIV Infections; Liver Failure; liver transplantation; Male; Middle Aged; Predictive Value of Tests; Preoperative Care; Research NIH Extramural; Risk Factors; Severity of Illness Index

Abstract:
<p>{BACKGROUND & AIMS: Human immunodeficiency virus (HIV) infection accelerates liver disease progression in patients with hepatitis C virus (HCV) and could shorten survival of those awaiting liver transplants. The Model for End-Stage Liver Disease (MELD) score predicts mortality in HIV-negative transplant candidates, but its reliability has not been established in HIV-positive candidates. METHODS: We evaluated predictors of pretransplantation mortality in HIV-positive liver transplant candidates enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR) matched 1:5 by age, sex, race, and HCV infection with HIV-negative controls from the United Network for Organ Sharing. RESULTS: Of 167 HIVTR candidates, 24 died (14.4%); this mortality rate was similar to that of controls (88/792, 11.1%</p>

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