Prevention of hospitalization due to respiratory syncytial virus: results from the Palivizumab Outcomes Registry.
2008 Jul
Journal Article
Authors:
Frogel, M.;
Nerwen, C.;
Cohen, A.;
VanVeldhuisen, P.;
Harrington, M.;
Boron, M.
Secondary:
J Perinatol
Volume:
28
Pagination:
511-7
Issue:
7
PMID:
18368063
Keywords:
Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiviral Agents; Hospitalization; Humans; Infant; Infant, Newborn; Infant, Premature; Palivizumab; Prospective Studies; Registries; Respiratory Syncytial Virus Infections
Abstract:
<p>OBJECTIVE: The Palivizumab Outcomes Registry contains data on infants and young children who received palivizumab for the prevention of respiratory syncytial virus (RSV) that causes serious lower respiratory tract illness.STUDY DESIGN: Prospective observational registry enrolling those who received >or=1 dose of palivizumab during any RSV season (2000 to 2004) at participating US sites.RESULT: Of 19 548 subjects enrolled, 40% were born before 32 weeks', 48% between 32 and 35 weeks' and 12% after 35 weeks' gestation. Risk factors included child-care attendance, prematurity, chronic lung disease (CLD) and congenital heart disease (CHD). The RSV hospitalization rate of palivizumab recipients was 1.3%. Gender, gestational age <32 weeks, CLD, CHD, congenital airway abnormality, severe neuromuscular disease, Medicaid insurance and >2 children in household were associated with significantly higher rates. Home-care prophylaxis with palivizumab was associated with reduced hospitalization rates.CONCLUSION: Data on the use of palivizumab prophylaxis in primarily high-risk infants confirm low RSV hospitalization rates.</p>