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Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort

Apr-13

Journal Article

Authors:

Gelman, B.

Lisinicchia, J.

Morgello, S.

Masliah, E.

Commins, D.

Achim, C.

Fox, H.

Kolson, D.

Grant, I.

Singer, E.

Yiannoutsos, C.

Sherman, S.

Gensler, G.

Moore, D.

Chen, T.

Soukup, V.

Secondary:
J Acquir Immune Defic Syndr

Volume:
62

Pagination:
487-495

URL:
http://www.ncbi.nlm.nih.gov/pubmed/23242157

Keywords:
dementia; encephalitis; HAND; HIVE; interferon; neurocognitive disorders

Abstract:
<p>{OBJECTIVE:: Replicating HIV-1 in the brain is present in HIV encephalitis (HIVE) and microglial nodule encephalitis (MGNE) and is putatively linked with HIV-associated neurocognitive disorders (HAND). A clinico-neurovirological correlation was conducted to elucidate the relationship between brain viral load and clinical phenotype. SUBJECTS: and assays: HIV gag/pol RNA and DNA copies were quantified with RT-PCR or PCR in 148 HAART-era brain specimens. Comparison to HAND, HIVE and MGNE and correlation with neuropsychological (NP) test scores were done using one-way ANOVA with Tukey-Kramer and Spearman's tests respectively. RESULTS:: Brain HIV RNA was higher in subjects with HAND plus HIVE vs without HAND (delta = 2.48 log10 units</p>

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